English+GermanWikipedia - /page/entry.mu

Micron Document

<!DOCTYPE html>

<title>Α-Globin</title>

</head>

<h1 id="firstHeading" class="firstHeading mw-first-heading">α-Globin</h1>

</header>

</div>

<th colspan="3" style="background:#90EE90; color:#202122;">Hämoglobin α-Untereinheit

</th></tr>

</td></tr>

<tr>

<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">Hb-Dimer: vorne α-Untereinheit als Cartoon-Modell mit Häm (rot, als VDW-Modell), hinten β-Untereinheit als Stäbchen, nach <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1GZX">1GZX</a>

</td></tr>

<tr>

Vorhandene Strukturdaten: <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P69905">UniProt-Eintrag</a>

</td></tr>

<tr>

<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>

</td>

<td colspan="2" style="text-align:center;">16'000 <a href="Atomare_Masseneinheit" title="Atomare Masseneinheit">Dalton</a>, 141 <a href="Aminos%C3%A4uren" title="Aminosäuren">Aminosäuren</a>

</td></tr>

<tr>

<td><a href="Koenzym" class="mw-redirect" title="Koenzym">Kofaktor</a>

</td>

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner

</th></tr>

<tr>

<td>Gen-Name(n)

</td>

</td></tr>

<tr>

<td>Externe IDs

</td>

<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P69905">P69905</a></li></ul>

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen

</th></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;">Homologie-Familie

</td>

<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P69905">Beta-2 Globin</a>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>

</td>

<td colspan="2" style="text-align:center;"><a href="Wirbeltiere" title="Wirbeltiere">Wirbeltiere</a>

</td></tr>

</tbody></table>

α-Globin, alpha-Globin, oder Hämoglobin alpha-Kette ist ein Protein aus der Familie der <a href="Globine" title="Globine">Globine</a>, dessen 142 <a href="Aminos%C3%A4uren" title="Aminosäuren">Aminosäuren</a> lange <a href="Polypeptid" class="mw-redirect" title="Polypeptid">Polypeptidkette</a> ein <a href="H%C3%A4m" class="mw-redirect" title="Häm">Häm</a> als <a href="Cofaktor_(Biochemie)" title="Cofaktor (Biochemie)">Cofaktor</a> bindet und das so Teil des <a href="Proteinkomplex" title="Proteinkomplex">Proteinkomplexes</a> von <a href="H%C3%A4moglobin" title="Hämoglobin">Hämoglobinen</a> in <a href="Wirbeltiere" title="Wirbeltiere">Wirbeltieren</a> ist, die Hämoglobin-<a href="Protein-Untereinheit" title="Protein-Untereinheit">Untereinheit</a> alpha (HBA1, HBA2).

<div class="mw-heading mw-heading2"><h2 id="Funktion">Funktion</h2></div>

Das menschliche Hämoglobin-α1-<a href="Gen-Cluster" title="Gen-Cluster">Gencluster</a> befindet sich auf <a href="Chromosom_16" class="mw-redirect" title="Chromosom 16">Chromosom 16</a>, umfasst 30 <a href="Kilobase" class="mw-redirect" title="Kilobase">Kilobasen</a> sowie sieben <a href="Genlocus" title="Genlocus">Loci</a>: 5'- ζ - pseudo-ζ - μ - pseudo-α-1 - α-2 - α-1 - θ - 3'. Die codierenden Sequenzen für α-2 (<a href="H%C3%A4moglobin%2C_alpha_2" class="mw-redirect" title="Hämoglobin, alpha 2">HBA2</a>) und α-1 (HBA1) sind identisch. Diese Gene unterscheiden sich nur wenig in der 5' nicht-<a href="Translation_(Biologie)" title="Translation (Biologie)">translatierten</a> Region sowie den <a href="Intron" title="Intron">Introns</a>, aber sie unterscheiden sich signifikant in der 3' nicht-translatierten Region. Zwei α-Ketten plus zwei β-Ketten bilden das Hämoglobin A (HbA), welches im normalen Erwachsenenleben ungefähr 97 % des gesamten <a href="H%C3%A4moglobin" title="Hämoglobin">Hämoglobins</a> umfasst; α-Ketten in Kombination mit delta-Ketten bilden das HbA-2, welches mit HbF („fetal hemoglobin“) die restlichen 3 % des Hämoglobins von Erwachsenen ausmacht. <a href="%CE%91-Thalass%C3%A4mie" title="Α-Thalassämie">α-Thalassämie</a> resultiert aus der <a href="Deletion" title="Deletion">Deletion</a> eines der α-Gene ebenso wie durch Deletion von sowohl HBA2 als auch HBA1; von einigen α-Thalassämien ohne Deletion wurden bereits berichtet.<a href="#cite_note-1">[1]</a>

<div class="mw-heading mw-heading2"><h2 id="Interaktion">Interaktion</h2></div>

α-Globin weist mit <a href="%CE%92-Globin" title="Β-Globin">β-Globin</a> <a href="Protein-Protein-Interaktion" title="Protein-Protein-Interaktion">Protein-Protein-Interaktion</a> auf.<a href="#cite_note-pmid16169070-2">[2]</a><a href="#cite_note-pmid6644819-3">[3]</a>

<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>

<li id="cite_note-1"><a href="#cite_ref-1">↑</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3039">Entrez Gene: HBA1 hemoglobin, alpha 1.</a> Abgerufen am 20. Mai 2012 (englisch).<span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3A%CE%91-Globin&rft.title=Entrez+Gene%3A+HBA1+hemoglobin%2C+alpha+1&rft.description=Entrez+Gene%3A+HBA1+hemoglobin%2C+alpha+1&rft.identifier=&rft.date=&rft.language=en">

</li>

<li id="cite_note-pmid16169070-2"><a href="#cite_ref-pmid16169070_2-0">↑</a> Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE: <cite class="lang" lang="en" dir="auto" style="font-style:italic">A human protein-protein interaction network: a resource for annotating the proteome</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Cell_(Zeitschrift)" title="Cell (Zeitschrift)">Cell</a></cite>. 122. Jahrgang, Nr. 6, September 2005, S. 957–68, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.cell.2005.08.029">10.1016/j.cell.2005.08.029</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/16169070?dopt=Abstract">PMID 16169070</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=A+human+protein-protein+interaction+network%3A+a+resource+for+annotating+the+proteome&rft.au=Stelzl+U%2C+Worm+U%2C+Lalowski+M%2C+...&rft.date=2005-09&rft.doi=10.1016%2Fj.cell.2005.08.029&rft.genre=journal&rft.issue=6&rft.jtitle=Cell&rft.pages=957-68&rft.pmid=16169070&rft.volume=122.+Jahrgang" style="display:none">

</li>

<li id="cite_note-pmid6644819-3"><a href="#cite_ref-pmid6644819_3-0">↑</a> Shaanan B: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Structure of human oxyhaemoglobin at 2.1 A resolution</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">J. Mol. Biol.</cite> 171. Jahrgang, Nr. 1, November 1983, S. 31–59, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016/S0022-2836%2883%2980313-1">10.1016/S0022-2836(83)80313-1</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/6644819?dopt=Abstract">PMID 6644819</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Structure+of+human+oxyhaemoglobin+at+2.1+A+resolution&rft.au=Shaanan+B&rft.date=1983-11&rft.doi=10.1016%2FS0022-2836%2883%2980313-1&rft.genre=journal&rft.issue=1&rft.jtitle=J.+Mol.+Biol.&rft.pages=31-59&rft.pmid=6644819&rft.volume=171.+Jahrgang" style="display:none">

</li>

</ol>

<div class="mw-heading mw-heading2"><h2 id="Weblinks">Weblinks</h2></div>

<ul><li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/NBK1435/">GeneReviews/NCBI/NIH/UW Eintrag bei α-Thalassemia</a></li>

<li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/141800,141850,142310,604131,141800,141850,142310,604131">OMIM-Einträge bei α-Thalassemia</a></li></ul>

<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>

<ul><li>Turbpaiboon C, Svasti S, Sawangareetakul P, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Hb Siam [alpha15(A13)Gly→Arg (alpha1) (GGT→CGT)] is a typical alpha chain hemoglobinopathy without an alpha-thalassemic effect.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Hemoglobin</cite>. 26. Jahrgang, Nr. 1, 2002, S. 77–81, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1081/HEM-120002944">10.1081/HEM-120002944</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11939517?dopt=Abstract">PMID 11939517</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Hb+Siam+%5Balpha15%28A13%29Gly%E2%86%92Arg+%28alpha1%29+%28GGT%E2%86%92CGT%29%5D+is+a+typical+alpha+chain+hemoglobinopathy+without+an+alpha-thalassemic+effect.&rft.au=Turbpaiboon+C%2C+Svasti+S%2C+Sawangareetakul+P%2C+...&rft.date=2002&rft.doi=10.1081%2FHEM-120002944&rft.genre=journal&rft.issue=1&rft.jtitle=Hemoglobin&rft.pages=77-81&rft.pmid=11939517&rft.volume=26.+Jahrgang" style="display:none"> </li>

<li>Yalçin A, Avcu F, Beyan C, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">A case of HB J-Meerut (or Hb J-Birmingham) [alpha 120(H3)Ala→Glu]</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Hemoglobin</cite>. 18. Jahrgang, Nr. 6, 1995, S. 433–5, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/7713747?dopt=Abstract">PMID 7713747</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=A+case+of+HB+J-Meerut+%28or+Hb+J-Birmingham%29+%5Balpha+120%28H3%29Ala%E2%86%92Glu%5D&rft.au=Yal%C3%A7in+A%2C+Avcu+F%2C+Beyan+C%2C+...&rft.date=1995&rft.genre=journal&rft.issue=6&rft.jtitle=Hemoglobin&rft.pages=433-5&rft.pmid=7713747&rft.volume=18.+Jahrgang" style="display:none"> </li>

<li>Giardina B, Messana I, Scatena R, Castagnola M: <cite class="lang" lang="en" dir="auto" style="font-style:italic">The multiple functions of hemoglobin.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Crit. Rev. Biochem. Mol. Biol.</cite> 30. Jahrgang, Nr. 3, 1995, S. 165–96, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109/10409239509085142">10.3109/10409239509085142</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/7555018?dopt=Abstract">PMID 7555018</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=The+multiple+functions+of+hemoglobin.&rft.au=Giardina+B%2C+Messana+I%2C+Scatena+R%2C+...&rft.date=1995&rft.doi=10.3109%2F10409239509085142&rft.genre=journal&rft.issue=3&rft.jtitle=Crit.+Rev.+Biochem.+Mol.+Biol.&rft.pages=165-96&rft.pmid=7555018&rft.volume=30.+Jahrgang" style="display:none"> </li>

<li>Higgs DR, Vickers MA, Wilkie AO, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">A review of the molecular genetics of the human alpha-globin gene cluster.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Blood_(Zeitschrift)" title="Blood (Zeitschrift)">Blood</a></cite>. 73. Jahrgang, Nr. 5, 1989, S. 1081–104, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/2649166?dopt=Abstract">PMID 2649166</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=A+review+of+the+molecular+genetics+of+the+human+alpha-globin+gene+cluster.&rft.au=Higgs+DR%2C+Vickers+MA%2C+Wilkie+AO%2C+...&rft.date=1989&rft.genre=journal&rft.issue=5&rft.jtitle=Blood&rft.pages=1081-104&rft.pmid=2649166&rft.volume=73.+Jahrgang" style="display:none"> </li>

<li>Schillirò G, Russo-Mancuso G, Dibenedetto SP, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Six rare hemoglobin variants found in Sicily.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Hemoglobin</cite>. 15. Jahrgang, Nr. 5, 1992, S. 431–7, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109/03630269108998862">10.3109/03630269108998862</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1802885?dopt=Abstract">PMID 1802885</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Six+rare+hemoglobin+variants+found+in+Sicily.&rft.au=Schillir%C3%B2+G%2C+Russo-Mancuso+G%2C+Dibenedetto+SP%2C+...&rft.date=1992&rft.doi=10.3109%2F03630269108998862&rft.genre=journal&rft.issue=5&rft.jtitle=Hemoglobin&rft.pages=431-7&rft.pmid=1802885&rft.volume=15.+Jahrgang" style="display:none"> </li>

<li>Vafa M, Troye-Blomberg M, Anchang J, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Multiplicity of Plasmodium falciparum infection in asymptomatic children in Senegal: relation to transmission, age and erythrocyte variants.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Malaria_Journal" title="Malaria Journal">Malaria Journal</a></cite>. 7. Jahrgang, 2008, S. 17, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1186/1475-2875-7-17">10.1186/1475-2875-7-17</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18215251?dopt=Abstract">PMID 18215251</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267475/">PMC 2267475</a> (freier Volltext) – (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Multiplicity+of+Plasmodium+falciparum+infection+in+asymptomatic+children+in+Senegal%3A+relation+to+transmission%2C+age+and+erythrocyte+variants.&rft.au=Vafa+M%2C+Troye-Blomberg+M%2C+Anchang+J%2C+...&rft.btitle=Malaria+Journal&rft.date=2008&rft.doi=10.1186%2F1475-2875-7-17&rft.genre=book&rft.pages=17&rft.pmc=2267475&rft.pmid=18215251&rft.volume=7.+Jahrgang" style="display:none"> </li>

<li>Datta P, Chakrabarty S, Chakrabarty A, Chakrabarti A: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Membrane interactions of hemoglobin variants, HbA, HbE, HbF and globin subunits of HbA: effects of aminophospholipids and cholesterol.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Biochim._Biophys._Acta" class="mw-redirect" title="Biochim. Biophys. Acta">Biochim. Biophys. Acta</a></cite>. 1778. Jahrgang, Nr. 1, 2008, S. 1–9, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.bbamem.2007.08.019">10.1016/j.bbamem.2007.08.019</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17916326?dopt=Abstract">PMID 17916326</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Membrane+interactions+of+hemoglobin+variants%2C+HbA%2C+HbE%2C+HbF+and+globin+subunits+of+HbA%3A+effects+of+aminophospholipids+and+cholesterol.&rft.au=Datta+P%2C+Chakrabarty+S%2C+Chakrabarty+A%2C+...&rft.date=2008&rft.doi=10.1016%2Fj.bbamem.2007.08.019&rft.genre=journal&rft.issue=1&rft.jtitle=Biochim.+Biophys.+Acta&rft.pages=1-9&rft.pmid=17916326&rft.volume=1778.+Jahrgang" style="display:none"> </li>

<li>Taylor JG, Ackah D, Cobb C, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Am. J. Hematol.</cite> 83. Jahrgang, Nr. 1, 2008, S. 6–14, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002/ajh.21035">10.1002/ajh.21035</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17724704?dopt=Abstract">PMID 17724704</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Mutations+and+polymorphisms+in+hemoglobin+genes+and+the+risk+of+pulmonary+hypertension+and+death+in+sickle+cell+disease.&rft.au=Taylor+JG%2C+Ackah+D%2C+Cobb+C%2C+...&rft.date=2008&rft.doi=10.1002%2Fajh.21035&rft.genre=journal&rft.issue=1&rft.jtitle=Am.+J.+Hematol.&rft.pages=6-14&rft.pmid=17724704&rft.volume=83.+Jahrgang" style="display:none"> </li>

<li>Sahu SC, Simplaceanu V, Gong Q, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Insights into the solution structure of human deoxyhemoglobin in the absence and presence of an allosteric effector.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Biochemistry" title="Biochemistry">Biochemistry</a></cite>. 46. Jahrgang, Nr. 35, 2007, S. 9973–80, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021/bi700935z">10.1021/bi700935z</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17691822?dopt=Abstract">PMID 17691822</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532491/">PMC 2532491</a> (freier Volltext) – (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Insights+into+the+solution+structure+of+human+deoxyhemoglobin+in+the+absence+and+presence+of+an+allosteric+effector.&rft.au=Sahu+SC%2C+Simplaceanu+V%2C+Gong+Q%2C+...&rft.date=2007&rft.doi=10.1021%2Fbi700935z&rft.genre=journal&rft.issue=35&rft.jtitle=Biochemistry&rft.pages=9973-80&rft.pmc=2532491&rft.pmid=17691822&rft.volume=46.+Jahrgang" style="display:none"> </li>

<li>Sorour Y, Heppinstall S, Porter N, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Is routine molecular screening for common alpha-thalassaemia deletions necessary as part of an antenatal screening programme?</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Journal of medical screening</cite>. 14. Jahrgang, Nr. 2, 2007, S. 60–1, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1258/096914107781261981">10.1258/096914107781261981</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17626702?dopt=Abstract">PMID 17626702</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Is+routine+molecular+screening+for+common+alpha-thalassaemia+deletions+necessary+as+part+of+an+antenatal+screening+programme%3F&rft.au=Sorour+Y%2C+Heppinstall+S%2C+Porter+N%2C+...&rft.date=2007&rft.doi=10.1258%2F096914107781261981&rft.genre=journal&rft.issue=2&rft.jtitle=Journal+of+medical+screening&rft.pages=60-1&rft.pmid=17626702&rft.volume=14.+Jahrgang" style="display:none"> </li>

<li>Hung CC, Lee CN, Chen CP, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Molecular assay of -alpha(3.7) and -alpha(4.2) deletions causing alpha-thalassemia by denaturing high-performance liquid chromatography.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Clin. Biochem.</cite> 40. Jahrgang, Nr. 11, 2007, S. 817–21, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.clinbiochem.2007.03.018">10.1016/j.clinbiochem.2007.03.018</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17512924?dopt=Abstract">PMID 17512924</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Molecular+assay+of+-alpha%283.7%29+and+-alpha%284.2%29+deletions+causing+alpha-thalassemia+by+denaturing+high-performance+liquid+chromatography.&rft.au=Hung+CC%2C+Lee+CN%2C+Chen+CP%2C+...&rft.date=2007&rft.doi=10.1016%2Fj.clinbiochem.2007.03.018&rft.genre=journal&rft.issue=11&rft.jtitle=Clin.+Biochem.&rft.pages=817-21&rft.pmid=17512924&rft.volume=40.+Jahrgang" style="display:none"> </li>

<li>Ye BC, Zhang Z, Lei Z: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Molecular analysis of alpha/beta-thalassemia in a southern Chinese population.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Genet. Test.</cite> 11. Jahrgang, Nr. 1, 2007, S. 75–83, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1089/gte.2006.0502">10.1089/gte.2006.0502</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17394396?dopt=Abstract">PMID 17394396</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Molecular+analysis+of+alpha%2Fbeta-thalassemia+in+a+southern+Chinese+population.&rft.au=Ye+BC%2C+Zhang+Z%2C+Lei+Z&rft.date=2007&rft.doi=10.1089%2Fgte.2006.0502&rft.genre=journal&rft.issue=1&rft.jtitle=Genet.+Test.&rft.pages=75-83&rft.pmid=17394396&rft.volume=11.+Jahrgang" style="display:none"> </li>

<li>Dilley J, Ganesan A, Deepa R, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Diabetes_Care" title="Diabetes Care">Diabetes Care</a></cite>. 30. Jahrgang, Nr. 6, 2007, S. 1527–32, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2337/dc06-2414">10.2337/dc06-2414</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17351274?dopt=Abstract">PMID 17351274</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Association+of+A1C+with+cardiovascular+disease+and+metabolic+syndrome+in+Asian+Indians+with+normal+glucose+tolerance.&rft.au=Dilley+J%2C+Ganesan+A%2C+Deepa+R%2C+...&rft.date=2007&rft.doi=10.2337%2Fdc06-2414&rft.genre=journal&rft.issue=6&rft.jtitle=Diabetes+Care&rft.pages=1527-32&rft.pmid=17351274&rft.volume=30.+Jahrgang" style="display:none"> </li>

<li>Fonseka PV, Vasudevan G, Clarizia LJ, McDonald MJ: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Temperature dependent soret spectral band shifts accompany human CN-mesohemoglobin assembly.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Protein J.</cite> 26. Jahrgang, Nr. 4, 2007, S. 257–63, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007/s10930-006-9067-7">10.1007/s10930-006-9067-7</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17191128?dopt=Abstract">PMID 17191128</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Temperature+dependent+soret+spectral+band+shifts+accompany+human+CN-mesohemoglobin+assembly.&rft.au=Fonseka+PV%2C+Vasudevan+G%2C+Clarizia+LJ%2C+...&rft.date=2007&rft.doi=10.1007%2Fs10930-006-9067-7&rft.genre=journal&rft.issue=4&rft.jtitle=Protein+J.&rft.pages=257-63&rft.pmid=17191128&rft.volume=26.+Jahrgang" style="display:none"> </li>

<li>Sankar VH, Arya V, Tewari D, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Genotyping of alpha-thalassemia in microcytic hypochromic anemia patients from North India.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">J. Appl. Genet.</cite> 47. Jahrgang, Nr. 4, 2007, S. 391–5, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007/BF03194650">10.1007/BF03194650</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17132905?dopt=Abstract">PMID 17132905</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Genotyping+of+alpha-thalassemia+in+microcytic+hypochromic+anemia+patients+from+North+India.&rft.au=Sankar+VH%2C+Arya+V%2C+Tewari+D%2C+...&rft.date=2007&rft.doi=10.1007%2FBF03194650&rft.genre=journal&rft.issue=4&rft.jtitle=J.+Appl.+Genet.&rft.pages=391-5&rft.pmid=17132905&rft.volume=47.+Jahrgang" style="display:none"> </li>

<li>Origa R, Sollaino MC, Giagu N, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Clinical and molecular analysis of haemoglobin H disease in Sardinia: haematological, obstetric and cardiac aspects in patients with different genotypes.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Br. J. Haematol.</cite> 136. Jahrgang, Nr. 2, 2007, S. 326–32, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111/j.1365-2141.2006.06423.x">10.1111/j.1365-2141.2006.06423.x</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17129226?dopt=Abstract">PMID 17129226</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Clinical+and+molecular+analysis+of+haemoglobin+H+disease+in+Sardinia%3A+haematological%2C+obstetric+and+cardiac+aspects+in+patients+with+different+genotypes.&rft.au=Origa+R%2C+Sollaino+MC%2C+Giagu+N%2C+...&rft.date=2007&rft.doi=10.1111%2Fj.1365-2141.2006.06423.x&rft.genre=journal&rft.issue=2&rft.jtitle=Br.+J.+Haematol.&rft.pages=326-32&rft.pmid=17129226&rft.volume=136.+Jahrgang" style="display:none"> </li>

<li>Hussein OA, Gefen Y, Zidan JM, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">LDL oxidation is associated with increased blood hemoglobin A1c levels in diabetic patients.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Clin. Chim. Acta</cite>. 377. Jahrgang, Nr. 1-2, 2007, S. 114–8, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.cca.2006.09.002">10.1016/j.cca.2006.09.002</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17070510?dopt=Abstract">PMID 17070510</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=LDL+oxidation+is+associated+with+increased+blood+hemoglobin+A1c+levels+in+diabetic+patients.&rft.au=Hussein+OA%2C+Gefen+Y%2C+Zidan+JM%2C+...&rft.date=2007&rft.doi=10.1016%2Fj.cca.2006.09.002&rft.genre=journal&rft.issue=1-2&rft.jtitle=Clin.+Chim.+Acta&rft.pages=114-8&rft.pmid=17070510&rft.volume=377.+Jahrgang" style="display:none"> </li>

<li>Pan W, Galkin O, Filobelo L, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Metastable mesoscopic clusters in solutions of sickle-cell hemoglobin.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Biophys. J.</cite> 92. Jahrgang, Nr. 1, 2007, S. 267–77, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1529/biophysj.106.094854">10.1529/biophysj.106.094854</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17040989?dopt=Abstract">PMID 17040989</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1697867/">PMC 1697867</a> (freier Volltext) – (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Metastable+mesoscopic+clusters+in+solutions+of+sickle-cell+hemoglobin.&rft.au=Pan+W%2C+Galkin+O%2C+Filobelo+L%2C+...&rft.date=2007&rft.doi=10.1529%2Fbiophysj.106.094854&rft.genre=journal&rft.issue=1&rft.jtitle=Biophys.+J.&rft.pages=267-77&rft.pmc=1697867&rft.pmid=17040989&rft.volume=92.+Jahrgang" style="display:none"> </li>

<li>Pistrosch F, Koehler C, Wildbrett J, Hanefeld M: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Relationship between diurnal glucose levels and HbA1c in type 2 diabetes.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Horm. Metab. Res.</cite> 38. Jahrgang, Nr. 7, 2006, S. 455–9, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1055/s-2006-947838">10.1055/s-2006-947838</a>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/16933182?dopt=Abstract">PMID 16933182</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Relationship+between+diurnal+glucose+levels+and+HbA1c+in+type+2+diabetes.&rft.au=Pistrosch+F%2C+Koehler+C%2C+Wildbrett+J%2C+...&rft.date=2006&rft.doi=10.1055%2Fs-2006-947838&rft.genre=journal&rft.issue=7&rft.jtitle=Horm.+Metab.+Res.&rft.pages=455-9&rft.pmid=16933182&rft.volume=38.+Jahrgang" style="display:none"> </li>

<li>Chong YM, Tan JA, Zubaidah Z, et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Screening of concurrent alpha-thalassaemia 1 in beta-thalassaemia carriers.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Med. J. Malaysia</cite>. 61. Jahrgang, Nr. 2, 2006, S. 217–20, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/16898315?dopt=Abstract">PMID 16898315</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:%CE%91-Globin&rft.atitle=Screening+of+concurrent+alpha-thalassaemia+1+in+beta-thalassaemia+carriers.&rft.au=Chong+YM%2C+Tan+JA%2C+Zubaidah+Z%2C+...&rft.date=2006&rft.genre=journal&rft.issue=2&rft.jtitle=Med.+J.+Malaysia&rft.pages=217-20&rft.pmid=16898315&rft.volume=61.+Jahrgang" style="display:none"> </li></ul></div><div><div class="zim-footer">

Dieser Artikel wurde von <a class="external text" title="Zuletzt bearbeitet am 2025-12-17" href="https://de.wikipedia.org/wiki/?title=%CE%91-Globin&oldid=262512023">Wikipedia</a> herausgegeben. Der Text ist unter <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.de">Creative Commons Attribution-Share Alike 4.0</a> verfügbar, sofern nicht anders angegeben. Für die Mediendateien können zusätzliche Bedingungen gelten.

</div>

</div></div>

</div>

</main>

</div>

</body></html>